PDR3 Antibody

1. Our results demonstrated that organic solvent stress was likely to damage mitochondria, causing generation of reactive oxygen species and mitochondrial fragmentation, and to activate retrograde signaling pathway via Pdr3p to upregulate PDR5 expression. PMID: 25487302
2. site-directed mutagenesis of Asp853 in Pdr3p; results indicate that, while Pdr3p can tolerate several substitutions of Asp853, the occurrence of a hydrophobic amino acid at this position has an adverse effect on its function PMID: 20146400
3. Pdr3p activation of RSB1 transcription is an important feature of the retrograde response allowing normal detoxification of an endogenous sphingolipid precursor. PMID: 16407254
4. We show that HSF activates expression of PDR3, encoding a multidrug resistance (MDR) transcription factor that also directly activates RPN4 gene expression. PMID: 16556235
5. These results demonstrate that amino acid residue Asp853 is essential for Pdr3p function, and indicate that specific loss-of-function pdr3 mutations can convert the Pdr3p transcription activator to a multicopy suppressor of multidrug resistance. PMID: 17266731
6. compounds with potential membrane-damaging or -perturbing effects might function as an activating signal for Pdr1 and Pdr3 PMID: 17881724
7. Overproduction of Psd1 in wild-type ([rho(+)]) cells was found to induce PDR5 transcription and drug resistance in a Pdr3-dependent manner. PMID: 18644857

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KEGG: sce:YBL005W

STRING: 4932.YBL005W