PEX5 Antibody

1. Cysteine-specific ubiquitination protects the peroxisomal import receptor Pex5p against proteasomal degradation. PMID: 26182377
2. Surface plasmon resonance analysis revealed a bivalent interaction mode for the phosphorylated PTS1 receptor Pex5 and Pcs60. PMID: 26359497
3. The membrane-associated import receptor Pex5p together with its docking partner Pex14p forms a gated ion-conducting channel which can be opened to a diameter of about 9 nm by the cytosolic receptor-cargo complex. PMID: 20154681
4. Data suggest that the N-terminal half of Pex5p facilitates the import of the major matrix protein Fox1p, and can be functionally replaced by Pex18p. PMID: 15456864
5. identified ubiquitinated forms of Pex5p in deletion mutants of those PEX genes that have been implicated in recycling of Pex5p from the peroxisomal membrane into the cytosol PMID: 15536088
6. Pex5p monoubiquitination in wild type cells is required for the recycling of Pex5p from the peroxisome, but Ubc4p-mediated polyubiquitination of Pex5p in mutants may function as a disposal mechanism for Pex5p when it gets stuck in the import pathway PMID: 15632140
7. Results demonstrate that the AAA peroxins mediate the ATP-dependent dislocation of the peroxisomal targeting signal-1 (PTS1) receptor from the peroxisomal membrane to the cytosol. PMID: 16007078
8. a translocation-competent state of the PTS1 receptor (Pex5p) enters the membrane via protein-lipid interactions before it tightly associates with other peroxins PMID: 16849337
9. Study demonstrated that either poly- or monoubiquitination of Pex5 is required for the ATP-dependent release of the protein from the peroxisomal membrane to the cytosol as part of the receptor cycle. PMID: 17452527
10. Pex4p-dependent ubiquitination of Pex5p occurs on a cysteine residue PMID: 17550898
11. E2D1/2/3 (UbcH5a/b/c) are the mammalian functional counterparts of yeast/plant Pex4p PMID: 18359941
12. The RING domain of Pex10p exhibits E(3) ligase activity in vitro, in combination with the human E(2) enzyme UbcH5a, a homologue of ScUbc4p, but not when ScPex4p is used as an E(2) enzyme in the reaction. PMID: 18644345
13. Pex2 mediates the Ubc4-dependent polyubiquitination whereas Pex12 facilitates the Pex4-dependent monoubiquitination of Pex5. PMID: 19687296

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KEGG: sce:YDR244W

STRING: 4932.YDR244W