PGRP-LC Antibody

1. cleaning behavior can be triggered through recognition of DAP-type PGN by its receptor PGRP-LC. PMID: 29121087
2. this study identifies a novel version of the peptidoglycan receptor PGRP-LC and demonstrate that it tunes immune responses to live (threatening) or dead (harmless) bacteria PMID: 27548432
3. PGRP-LC immune receptor regulates trans-synaptic signaling, a novel activity for innate immune signaling. PMID: 26687223
4. The steroid hormone ecdysone controls the expression of the pattern recognition receptor PGRP-LC in Drosophila, thereby tightly regulating innate immune recognition and defense against bacterial infection. PMID: 23652443
5. Data show that the Drosophila peptidoglycan-recognition protein LF interacts with peptidoglycan-recognition protein LC to downregulate the Imd pathway. PMID: 21372849
6. required for the induction of antibacterial peptide genes in response to infection in Drosophila and acts by controlling activation of the NF-kappaB family transcription factor Relish PMID: 11872802
7. Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. PMID: 11912488
8. Drosophila receptor for E. coli: essential component for recognition and signalling of Gram-negative bacteria PMID: 11912489
9. Using RNA interference in Drosophila mbn-2 cells, we found that PGRP-LCx is the only isoform required to mediate signals from Gram-positive bacteria and purified bacterial peptidoglycan. PMID: 12777387
10. PGRP-LC functions synergistically with PGRP-LE in producing resistance to Escherichia coli and Bacillus megaterium infections. PMID: 15538387
11. PGRP-LC acts as a signal-transducing innate immune receptor. PMID: 15657141
12. crystal structure at 2.1 angstrom resolution of tracheal cytotoxin (TCT) in complex with the ectodomains of PGRP-LCa and PGRP-LCx shows that TCT is bound to and presented by the LCx ectodomain for recognition by the LCa ectodomain PMID: 16556841
13. Interaction with the imd signaling protein is not required for PGRP-LC signaling. Instead, PGRP-LC signals through a receptor-interacting protein homotypic interaction motif-like motif. PMID: 16767093
14. Toll and immune deficiency pathway of PGRP-LC activate an immune response in Drosophila melanogaster. PMID: 17438142
15. Cleavage or down-regulation of PGRP-LC may provide an additional cue for the host to distinguish pathogenic microbes and subsequently activate multiple host defense systems in Drosophila, thereby combating bacterial infection and initiating tissue repair. PMID: 18308747
16. By genetically interacting with PGRP-LC, PGRP-LF prevents constitutive activation of both the JNK and the immune deficiency pathways in the absence of infection. PMID: 18474356

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KEGG: dme:Dmel_CG4432

STRING: 7227.FBpp0088492

UniGene: Dm.1437