plc Antibody

Datasheet

Code	CSB-PA610762XA01FWJ
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Product Details

Full Product Name

Rabbit anti-Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A) plc Polyclonal antibody

Uniprot No.

Q0TV31

Target Names

plc

Alternative Names

plc antibody; cpa antibody; CPF_0042 antibody; Phospholipase C antibody; PLC antibody; EC 3.1.4.3 antibody; Alpha-toxin antibody; Hemolysin antibody; Lecithinase antibody; Phosphatidylcholine cholinephosphohydrolase antibody

Raised in

Rabbit

Species Reactivity

Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)

Immunogen

Recombinant Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A) plc protein

Immunogen Species

Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Constitutes an essential virulence factor in gas gangrene. Binds to eukaryotic membranes where it hydrolyzes both phosphatidylcholine and sphingomyelin. The diacylglycerol produced can activate both the arachidonic acid pathway, leading to modulation of the inflammatory response cascade and thrombosis, and protein kinase C, leading to activation of eukaryotic phospholipases and further membrane damage. Acts on human and mouse erythrocytes, but not on rabbit or horse erythrocytes.

Gene References into Functions

In vitro treatment of isolated bone marrow cells with alpha-toxin (phospholipase C) revealed that alpha-toxin directly decreased mature neutrophils. alpha-Toxin did not influence the viability of isolated mature neutrophils, while simultaneous treatment of bone marrow cells with granulocyte colony-stimulating factor attenuated the reduction of mature neutrophils by alpha-toxin. PMID: 27306065

Subcellular Location

Secreted.

Protein Families

Bacterial zinc-metallophospholipase C family

Database Links

KEGG: cpf:CPF_0042

STRING: 195103.CPF_0042

Promotions

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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plc Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background