PID Antibody

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Code	CSB-PA530162XA01DOA
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Target Background

Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) PID Polyclonal antibody

Uniprot No.

O64682

Target Names

PID

Alternative Names

PID antibody; ABR antibody; At2g34650 antibody; T31E10.1 antibody; Protein kinase PINOID antibody; EC 2.7.11.1 antibody; Protein kinase ABRUPTUS antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana PID protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Serine/threonine-protein kinase involved in the regulation of auxin signaling. Acts as a positive regulator of cellular auxin efflux and regulates organ development by enhancing polar auxin transport. Phosphorylates conserved serine residues in the PIN auxin efflux carriers. Phosphorylation of PIN proteins is required and sufficient for apical-basal PIN polarity that enables directional intercellular auxin fluxes, which mediate differential growth, tissue patterning and organogenesis. Acts in association with PIN1 to control the establishment of bilateral symmetry and promotion of cotyledon outgrowth. Regulates root gravitropism through modulation of PIN2-dependent basipetal auxin transport. Required for polarization of PIN3-dependent auxin transport for hypocotyl gravitropic response. The protein kinase activity of PID is essential for its auxin efflux regulatory function. PID kinase and PP2A phosphatase activities antagonistically regulate phosphorylation of PIN proteins, affecting PIN sorting.

Gene References into Functions

PID, but not D6PK, can also induce PIN1 polarity shifts, seemingly through phosphorylation at S1-S3. Phosphosite preferences are not sufficient to explain these differential effects of D6PK and PID on PIN1 polarity. PMID: 28096328
CK2 also plays a key role in the transcriptional regulation of PINOID (PID), an AGC protein kinase that modulates the apical/basal localization of auxin-efflux transporters. PMID: 27275924
PID is necessary for phytochrome-mediated enhancement of hypocotyl phototropism in Arabidopsis. PMID: 25281709
PIN-mediated auxin transport is directly activated by D6 PROTEIN KINASE (D6PK) and PINOID (PID)/WAG kinases of the Arabidopsis AGCVIII kinase family PMID: 24948515
Both PIN3 polarization and hypocotyl bending require the activity of the trafficking regulator GNOM and the protein kinase PINOID. PMID: 21569134
Interaction between the PINOID/ABRUPTUS gene with the AGAMOUS gene: the negative regulator of stem cells in the meristem of Arabidopsis thaliana flower PMID: 21542343
show that PID, WAG1 and WAG2, and not other plant AGC kinases, instruct recruitment of PINs into the apical recycling pathway by phosphorylating the middle serine in three conserved TPRXS(N/S) motifs within the PIN central hydrophilic loop PMID: 20823065
PID regulates PIN1 polar localization through reversible phosphorylation. PMID: 20407025
Interaction between the ABRUPTUS/PINOID and APETALA1 genes regulating the inflorescence development in Arabidopsis thaliana PMID: 20391782
PID and GNOM antagonistically regulate PIN polarity and plant development. PID induces PIN sorting into a GNOM-independent pathway PMID: 20040538
role in establishment of bilateral symmetry, as well as in the promotion of cotyledon outgrowth PMID: 15371311
results show that a PINOID-dependent binary switch controls PIN polarity and mediates changes in auxin flow to create local gradients for patterning processes PMID: 15514156
PDK1 is a potent enhancer of PID activity. PMID: 16601102
Results suggest that PINOID positively regulates cellular auxin efflux, most likely by modulating the trafficking of PIN and/or some other molecular partners involved in auxin efflux. PMID: 16731587
MAB4/ENHANCER OF PINOID is involved in polar auxin transport in organogenesis PMID: 17913786
Reduced PID kinase function inhibits gravitropism and basipetal indole-3-acetic acid transport. PMID: 19363095

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Subcellular Location

Cytoplasm, cytosol. Note=Targeted to the cell periphery.

Protein Families

Protein kinase superfamily, Ser/Thr protein kinase family

Tissue Specificity

Expressed in root hair cells, shoot xylem parenchyma cells and endodermis around the vasculature. Expressed in anther primordia, vasculature of the growing flower stalk, young pedicels and bracts and developing sepals, but not in petals. In pistils, trans

Database Links

KEGG: ath:AT2G34650

STRING: 3702.AT2G34650.1

UniGene: At.19528

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PID Antibody

Product Details

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Target Background