Plc21C Antibody

Code CSB-PA335120XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Plc21C Polyclonal antibody
Uniprot No.
Target Names
Plc21C
Alternative Names
Plc21C antibody; plc-21 antibody; CG4574 antibody; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II antibody; EC 3.1.4.11 antibody; Phosphoinositide phospholipase C antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Plc21C protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Gene References into Functions
  1. Galphaq, Ggamma1 and Plc21C are anti-obesity genes and Akh employs the Galphaq/Ggamma1/Plc21C module of iCa(2+) control to regulate lipid mobilization in adult Drosophila. PMID: 24894355
  2. These results are consistent with a model in which phosphatidylinositol 4,5-bisphosphate hydrolysis acts via Ca2+ to activate myosin via MLCK and thereby control actin dynamics during constriction of the contractile ring. PMID: 17509155
  3. Reduced odor responses from antennal neurons of phospholipase Cbeta mutants in Drosophila support a role for a phospholipid intermediate in insect olfactory transduction. PMID: 18448651
  4. Disruption of PLCb4 function completely blocked light-dependent modulation of Shab currents in Drosophila photoreceptors. PMID: 18760696
Tissue Specificity
Expressed in neuronal cell bodies of the optic lobe, central brain, and thoracic ganglia in adults, and the brain of larvae.
Database Links

KEGG: dme:Dmel_CG4574

STRING: 7227.FBpp0089226

UniGene: Dm.4674

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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