pip Antibody

1. Pipe modifies proteins that are incorporated in the ventral eggshell and activate Toll signaling which in turn initiates embryonic dorsoventral patterning. PMID: 22198544
2. promotes 6-O- and/or N-sulfation of heparan sulfate but is not required for heparan sulfate 2-O-sulfation PMID: 18719407
3. no requirement for nudel to be expressed in ventral, pipe-expressing follicle cells PMID: 18776742
4. observation suggests a mechanism in which the sulfated target of Pipe promotes a productive interaction between Snake and Easter, perhaps by facilitating conformational changes in a complex containing the two proteins PMID: 20605458
5. Snake activation is cascade-dependent but pipe-independent. Snake's activation of Easter is the first spatially regulated step in the dorsoventral protease cascade. PMID: 20638387
6. Pipe induces ventral cell fates in the embryo via activation of the Spatzle/Toll pathway. PMID: 12050143
7. Pipe acts as a sulfotransferase PMID: 16049108
8. Sulfation of eggshell components by Pipe defines dorsal-ventral polarity in the Drosophila embryo. PMID: 19540119
9. Data indicate that differences in functional specificity, and presumably enzymatic specificity, are associated with several of the Pipe isoforms. PMID: 19633171

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KEGG: dme:Dmel_CG9614

STRING: 7227.FBpp0074780

UniGene: Dm.19224