Pitpna Antibody

Code CSB-PA018035XA01MO
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Pitpna Polyclonal antibody
Uniprot No.
Target Names
Pitpna
Alternative Names
Pitpna antibody; Pitpn antibody; Phosphatidylinositol transfer protein alpha isoform antibody; PI-TP-alpha antibody; PtdIns transfer protein alpha antibody; PtdInsTP alpha antibody
Raised in
Rabbit
Species Reactivity
Mus musculus (Mouse)
Immunogen
Recombinant Mus musculus (Mouse) Pitpna protein
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes. Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions. Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3.
Gene References into Functions
  1. platelet PITPalpha-mediated phosphoinositide signaling is inconsequential for in vivo hemostasis. PMID: 29084966
  2. These results indicate a mechanism of suppression that bypasses a quantitative requirement for PITPalpha function. PMID: 21321132
  3. Data suggest that phosphatidylinositol transfer protein (PITP) beta is an essential housekeeping PITP in murine cells, whereas PITP alpha plays a far more specialized function in mammals. PMID: 11907258
  4. PITP alpha has a role with glucose homeostasis and in mammalian endoplasmic reticulum functions that interface with transport of specific luminal lipid cargoes PMID: 12788952
  5. The PITPalpha function in murine cells has no deleterious consequences for growth and bulk phospholipid metabolism. PMID: 15052341
  6. Involved in phosphoionoitide homeostasis and signal transsduction (review) PMID: 15581491
  7. These results identify a crucial role for PlTPalpha in netrin-1-induced neurite outgrowth, revealing a signalling mechanism for DCC/neogenin and PlTPalpha regulation. PMID: 16244667
  8. phosphatidylinositol binding is an essential functional property of PITPalpha in vivo, and suggest a causal linkage between defects in lipid transport and glucose homeostasis and cerebellar inflammatory disease PMID: 17525475

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Involvement in disease
Defects in Pitpna are the cause of the vibrator phenotype which is characterized by early-onset progressive action tremor, degeneration of brain stem and spinal cord neurons, and juvenile death. The mutation is due to the insertion of an intracisternal A particle retrotransposon in intron 4 which results in a 5-fold reduction in protein levels.
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
PtdIns transfer protein family, PI transfer class I subfamily
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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