PKH1 Antibody

1. Thus, Sch9 is a Cst6/Rca1 kinase that links CO2 adaptation to lipid signaling via Pkh1/2 in fungi. PMID: 28143980
2. PI kinase-mediated Endoplasmic Reticulum-Plasma Membrane cross-talk comprises a regulatory system that ensures cellular integrity under membrane stress conditions. PMID: 26864629
3. Data indicate that mutant nce102 sng1 cells show features of impaired Pkh/Ypk signalling, including increased reactive oxygen species accumulation. PMID: 27033517
4. Serine, threonine and valine activated a signaling network in which Sch9 integrates TORC1 and Pkh signaling via phosphorylation of threonines 570 and 737 PMID: 24516402
5. These results suggest that sphingolipid signalling through Pkh1p-Sch9p mediate mitochondrial dysfunction, oxidative stress sensitivity and shortened chronological lifespan in the yeast model of Niemann-Pick type C disease. PMID: 24286211
6. Vps27 phosphorylation by Pkh1/2 kinases regulates the coordinated cascade of endosomal sorting complex required for transport complex recruitment at the endosomal membrane. PMID: 22918958
7. Pkh1 protein kinase contributes to the divergent regulation of protein kinase A catalytic subunits. PMID: 22957732
8. Nutrients and the Pkh1/2 and Pkc1 protein kinases control mRNA decay and P-body assembly in yeast PMID: 21163942
9. phytosphingosine, rather than simply being an upstream activator of Pkh1, also activates kinases that are downstream targets of Pkh1 including Ypk1/2 and Sch9 PMID: 15840588
10. Data suggest that Pkh1 signaling relayed to Pil1 may help regulate endocytic events to modulate the organization of the plasma membrane. PMID: 18034155
11. endocytosis is regulated by the sphingolipid-Pkh1/2-Ypk1/2 signaling pathway and Pkh1 and -2 respond to changes in membrane sphingolipids and transmit this information to eisosomes via Pil1 phosphorylation PMID: 18296441

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KEGG: sce:YDR490C

STRING: 4932.YDR490C