egl-8 Antibody

Code CSB-PA914611XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans egl-8 Polyclonal antibody
Uniprot No.
Target Names
egl-8
Alternative Names
egl-8 antibody; B0348.4 antibody; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 antibody; EC 3.1.4.11 antibody; Egg-laying defective protein 8 antibody; Phosphoinositide phospholipase C-beta egl-8 antibody; Phospholipase C-beta egl-8 antibody; PLC-beta egl-8 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans egl-8 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades. Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion. Plays a role in efficient egg laying and defecation. Involved in axon regeneration after injury. Plays a role in male mating behavior by regulating spicule insertion and sperm transfer. By triggering Ca(2+) transient via IP3-mediated activation of IPR3 receptor itr-1 in ASH sensory neurons, regulates avoidance behavior in response to nose touch. By activating tpa-1 via DAG production, required for the expression of antimicrobial peptide nlp-29 in response to fungal infection. During embryogenesis, may play a role in epidermal morphogenesis together with plc-1.
Subcellular Location
Perikaryon. Cell projection, axon. Cell junction, synapse. Cell junction, adherens junction.
Tissue Specificity
Expressed in most or all neurons with high expression in the head and tail ganglia and low expression in the motor neurons of the ventral cord. Expressed in the intestine (at protein level). In males, expressed in vas deferens, spicule protractor muscles,
Database Links

STRING: 6239.B0348.4b

UniGene: Cel.6072

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