plc-3 Antibody

Code CSB-PA913744XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans plc-3 Polyclonal antibody
Uniprot No.
Target Names
plc-3
Alternative Names
plc-3 antibody; T01E8.3 antibody; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3 antibody; EC 3.1.4.11 antibody; Phosphoinositide phospholipase C-gamma plc-3 antibody; Phospholipase C-gamma plc-3 antibody; PLC-gamma plc-3 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans plc-3 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (Probable). Regulates basal and ovulatory sheath cell contractions by controlling Ca(2+) oscillations via IP3-mediated activation of IP3 receptor itr-1. In intestinal epithelial cells, regulates Ca(2+) oscillations which control posterior body wall muscle contractions required for defecation by IP3-mediated activation of itr-1 and probably by activating TRPM channels gon-2 and gtl-1 by reducing PIP2 levels. By activating tpa-1 via DAG production, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury. By triggering Ca(2+) transient via IP3-mediated activation of IPR3 receptor itr-1 in ASH sensory neurons, involved in avoidance behavior in response to nose touch. Probably by regulating neuronal transmission in ALA neurons, mediates the decrease in pharyngeal pumping and locomotion during the quiescent state that precedes each larval molt, downstream of lin-3 and receptor let-23 and upstream of tpa-1 but not itr-1. During embryogenesis, may play an role in epidermal morphogenesis together with plc-1. Probably downstream of receptor daf-2, regulates male-sex muscle excitability in the absence of food.
Tissue Specificity
Expressed in intestine, isthmus of the pharynx, proximal gonad sheath cells, spermatheca and uterine sheath cells. In males, expressed in the valve cell, the vas deferens and retractor and ventral protactor muscles.
Database Links

KEGG: cel:CELE_T01E8.3

STRING: 6239.T01E8.3

UniGene: Cel.14497

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