plk-1 Antibody

Datasheet

Code	CSB-PA339442XA01CXY
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Target Background

Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans plk-1 Polyclonal antibody

Uniprot No.

P34331

Target Names

plk-1

Alternative Names

plk-1 antibody; plc1 antibody; C14B9.4 antibody; Serine/threonine-protein kinase plk-1 antibody; EC 2.7.11.21 antibody; Polo-like kinase 1 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans plk-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Required for oocyte nuclear envelope breakdown before entry of oocyte into spermatheca. In meiotic cells, required for spindle dynamics and probably for spindle attachment to the chromosomes. Zygotic role in the development of the germline and nerve cord. In mitotic cells, plays a role in spindle organization and centrosome maturation. Involved in asymmetric nuclear localization of cdc-25.1 during embryogenesis which affects cell division timing. Together with plk-2, regulates cytoplasm polarity in early embryos. May play a minor role in chromosome pairing and synapsis during oocyte meiosis I.

Gene References into Functions

PLK1 inhibition mitigates autophagy in cancer cells both under nutrient starvation and sufficiency, and a role of PLK1 in autophagy is also observed in the invertebrate model organism Caenorhabditis elegans. PMID: 28102733
These results reveal a crucial and conserved role of phosphorylation of the N terminus of Bora for Plk1 activation and mitotic entry. PMID: 27068477
Our data further show that PLK-1 is needed for nuclear envelope breakdown during early embryogenesis PMID: 26490119
PLK-1 substitutes for Mps1 in controlling spindle checkpoint initiation in C. elegans. PMID: 26119738
NCAPG2 plays an important role in regulating proper chromosome segregation through a functional interaction with PLK1 during mitosis PMID: 25109385
The result provide key insights into the regulation of homolog pairing and reveal that targeting of plk-1 to the NE by meiotic chromosomes establishes the conserved linkages to cytoskeletal forces needed for homology assessment. PMID: 22018921
plk-1 asymmetry contributes to asynchronous cell division in C. elegans embryos. PMID: 18305005

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Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Cytoplasm. Nucleus. Chromosome. Chromosome, centromere, kinetochore.

Protein Families

Protein kinase superfamily, Ser/Thr protein kinase family, CDC5/Polo subfamily

Tissue Specificity

Embryos.

Database Links

KEGG: cel:CELE_C14B9.4

STRING: 6239.C14B9.4b

UniGene: Cel.18095

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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plk-1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background