Pmm2 Antibody

Code CSB-PA893804XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Pmm2 Polyclonal antibody
Uniprot No.
Target Names
Pmm2
Alternative Names
CG10688 antibody; Probable phosphomannomutase antibody; PMM antibody; EC 5.4.2.8 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Pmm2 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. Required for maintaining N-linked glycoprotein glycosylation at the neuromuscular junction (NMJ) synaptomatrix, and thus acts in multiple pathways that prevent NMJ structural overgrowth, restrict synaptic bouton differentiation, and limit NMJ neurotransmission strength, in order to maintain viability, coordinate movement, and in adults ensure correct wing positioning. Acts in the NMJ trans-synaptic Wg pathway via glycosylation of synaptic Mmp2 which enables dlp/wg signaling during development.
Gene References into Functions
  1. CRISPR-generated pmm2-null Drosophila mutants display severely disrupted glycosylation and early lethality. PMID: 26940433
Subcellular Location
Cytoplasm.
Protein Families
Eukaryotic PMM family
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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