PMS1 Antibody

Datasheet

Code	CSB-PA185082XA01DOA
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) PMS1 Polyclonal antibody

Uniprot No.

Q941I6

Target Names

PMS1

Alternative Names

PMS1 antibody; At4g02460 antibody; T14P8.6 antibody; DNA mismatch repair protein PMS1 antibody; Postmeiotic segregation protein 1 antibody; Protein POSTMEIOTIC SEGREGATION 1 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana PMS1 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

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Target Background

Function

Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLalpha heterodimer that forms a ternary complex with the MutS heterodimers, which initially recognize the DNA mismatches. This complex is thought to be responsible for directing the downsteam MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in maintaining the genetic stability of simple sequence repeats and in the repair of heteroduplex sites present in meiotic recombination intermediates. Does not seem to be required for homologous somatic recombination.

Gene References into Functions

AtPMS1 overexpression should be affecting yeast genomic stability, very possibly by preventing necessary interactions between plant and yeast proteins, which are required to complete MMR. PMID: 23184005
analysis of Arabidopsis thaliana PMS1 expression and distribution in a bacterial host PMID: 20571910
Results indicate that the AtPMS1 gene contributes to an antirecombination activity aimed at restricting recombination between diverged sequences PMID: 19115045

Subcellular Location

Nucleus.

Protein Families

DNA mismatch repair MutL/HexB family

Tissue Specificity

Expressed at very low levels in mature leaves. Detected in rapidly dividing tissues.

Database Links

KEGG: ath:AT4G02460

STRING: 3702.AT4G02460.1

UniGene: At.26416

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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