ORF1 Antibody

Datasheet

Code	CSB-PA757844XA01FWK
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Target Background

Product Details

Full Product Name

Rabbit anti-Sapporo virus (isolate GII/Human/Thailand/Mc10/2000) (Hu/SaV/Mc10/2000/Thailand) ORF1 Polyclonal antibody

Uniprot No.

Q6XDK8

Target Names

ORF1

Alternative Names

ORF1 antibody; Genome polyprotein [Cleaved into: Protein p11; Protein p28; NTPase antibody; EC 3.6.1.15 antibody; p35); Protein p32; Viral genome-linked protein antibody; VPg antibody; p14); Protease-polymerase p70 antibody; Pro-Pol antibody; EC 2.7.7.48 antibody; EC 3.4.22.66); Capsid protein antibody; CP antibody; VP1 antibody; p60)] antibody

Raised in

Rabbit

Species Reactivity

Sapporo virus (isolate GII/Human/Thailand/Mc10/2000) (Hu/SaV/Mc10/2000/Thailand)

Immunogen

Recombinant Sapporo virus (isolate GII/Human/Thailand/Mc10/2000) (Hu/SaV/Mc10/2000/Thailand) ORF1 protein

Immunogen Species

Sapporo virus (isolate GII/Human/Thailand/Mc10/2000) (Hu/SaV/Mc10/2000/Thailand)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity.; Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation.; Protease-polymerase p70 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved. It is also an RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Catalyzes the covalent attachment VPg with viral RNAs.; Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm.

Gene References into Functions

This study suggested the recombination site was at the polymerase-capsid junction within open reading frame one PMID: 15504283
ORF1 polyprotein is processed into at least 10 major proteins: p11, p28, p35, p32, p14, p70, p60, p66, p46, and p120 by 3C-like protease PMID: 15919882
VP1 cleaved from a part of ORF1 polyprotein self-assembled into virus-like particles in COS-7 cell. PMID: 19161558

Subcellular Location

[Capsid protein]: Virion. Host cytoplasm.

Database Links

KEGG: vg:2943313

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Email: [email protected]
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Service

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Protein Service

Gene Synthesis Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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ORF1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background