Polk Antibody

1. The results suggest that Polk has a limited ability to suppress BP-induced genotoxicity in the colon and bone marrow and also that the roles of specialized DNA polymerases in mutagenesis and carcinogenesis should be examined not only by in vitro assays but also by in vivo mouse studies. We also report the spontaneous mutagenesis in inactivated Polk KI mice at young and old ages. PMID: 29076178
2. the extreme N-terminal part of Polkappa is required for the processivity and fidelity of Polkappa during translesion synthesis of 10S(+)-trans-anti-benzo[a]pyrene diol epoxide-N(2)-deoxyguanine adducts lesions. PMID: 26634445
3. Polk plays a predominant role in suppressing point mutations by carrying out error-free translesion DNA synthesis and contributes to the prevention of DNA strand breaks. PMID: 25303778
4. The structural gap physically accommodates the bulky aromatic adduct and the N-clasp is essential for the structural integrity and flexibility of Polkappa during translesion synthesis. PMID: 24449898
5. Polkappa accumulates at laser-induced sites of DNA damage. PMID: 23522793
6. Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) zeta, and Pol kappa PMID: 22859295
7. Data suggest that DNA polymerase kappa Polkappa functions in DNA interstrand crosslinks (ICLs) repair in embryonic fibroblast cells (MEF), especially during the G0/G1 phases. PMID: 22658724
8. solution structure of the polymerase kappa-Rev1 complex PMID: 22700975
9. results are consistent with the notion that Pol kappa is required for accurate translesion DNA synthesis past naturally occurring polycyclic guanine adducts, possibly generated by cholesterol and/or its metabolites. PMID: 19783230
10. Polkappa plays an important role in suppressing mutations at DNA lesions generated by benzo[a]pyrene, but not UV or x-ray irradiation. PMID: 12432099
11. Rev7 competes directly with Pol kappa for binding to the Rev1 C-terminus. PMID: 14657033
12. The multiple mouse/human (PolK/POLK) transcripts may encode multiple Polkappa isoforms in testis PMID: 15661663
13. the trans-lesion synthesis enzyme polkappa is specifically required for normal recovery from the BPDE-induced S-phase checkpoint PMID: 15817457
14. Polk causes error-prone and inefficient replication across 8-oxoguanine in ras genes. PMID: 15938713
15. Polkappa has a function in translesion DNA synthesis past alkylated base adducts as well as UV radiation DNA damage in vertebrates PMID: 16308320
16. compromised translesion synthesis in Polkappa(-/-) mice may result in replication fork pausing which, in turn, may affect expanded simple tandem repeat mutation rate PMID: 16731053
17. pol kappa-deficient mouse cells have substantially reduced (but not absent) levels of nucleotide excision repair PMID: 16738703
18. Polkappa binds with monoubiquitinated proliferating cell nuclear antigen (PCNA) more robustly than with non-ubiquitinated PCNA. PMID: 18162470
19. The REV1-interaction is essential for Polkappa function in vivo. PMID: 19170759

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KEGG: mmu:27015

STRING: 10090.ENSMUSP00000022172

UniGene: Mm.89926