polo Antibody

1. Polo is composed of an N-term kinase domain (KD) and a C-term polo-box domain (PBD), which regulates its subcellular localizations. PBD binding to the KD masks a nuclear localization signal (NLS). Activating phosphorylation of the KD leads to exposure of the NLS and entry of Polo into the nucleus before nuclear envelope breakdown. PMID: 29167465
2. Polo is an important in vivo regulator of the pathological functions of APP. PMID: 26597721
3. Both conditions impaired NSC lineage progression. Ca(2) mito homeostasis is influenced by Polo-mediated phosphorylation of a conserved residue in Miro PMID: 27093086
4. Polo kinase is required for localization and activity of the chromosomal passenger complex in mitosis and meiosis. PMID: 25376909
5. Centrioles, which usually separate during the anaphase of the first meiosis, remained held together in a V-shaped configuration suggesting that Polo kinase regulates the proteolysis that breaks centriole linkage to ensure their disengagement. PMID: 24802643
6. Results show that Polo kinase positively and negatively regulates Augmin distribution for microtubule nucleation and acentrosomal spindle formation. PMID: 24829288
7. our results indicate that polo forms a gene loop and polo transcription termination occurs by an Xrn2 and Pcf11 independent mechanism that requires TFIIB. PMID: 22992452
8. Jumu and CHES-1-like control the division of cardiac progenitors by regulating the activity of Polo, a kinase involved in multiple steps of mitosis. PMID: 22814603
9. POLO is required to promote amphitelic attachment and chromosome bi-orientation by regulating both the activity of the correction mechanism and the architecture of the centromere. PMID: 22389397
10. Polo and protein phosphatase 2A collaborate to ensure centrosome attachment to nuclei PMID: 21852958
11. In transgenic flies, a polo poly(A) signal in the 3' untranslated region is necessary for proper protein production level, cell proliferation and viability in the living organism. PMID: 21602789
12. results reveal that the Feo/Klp3A complex is necessary for Polo recruitment to the spindle midzone; data imply that Polo recruitment to the central spindle is not required for furrowing, but some other aspect of cytokinesis PMID: 17593971
13. mps1 and polo are sequestered to collagenase-sensitive filaments in Drosophila prometaphase oocytes under hypoxic conditions PMID: 19847308
14. These results indicate that Gwl activity antagonizes Polo and thus identify an important regulatory interaction of the cell cycle. PMID: 17997611
15. suggest a model in which the eventual activation of Cdc25 by an excess of Polo at stage 13 triggers nuclear envelope breakdown and entry into prometaphase PMID: 18052611
16. The depletion of Polo results in a strong prometa/metaphase arrest with the spindle checkpoint activated in response to lack of tension PMID: 18719370
17. Map205-dependent targeting of Polo to microtubules provides a stable reservoir of Polo that can be rapidly mobilized by the activity of Cdk1 at mitotic entry. PMID: 18832073

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KEGG: dme:Dmel_CG12306

STRING: 7227.FBpp0074608

UniGene: Dm.2513