pom1 Antibody

1. Results demonstrate that Pom1 auto-phosphorylates intermolecularly, both in vitro and in vivo, which confers robustness to the gradient. PMID: 26150232
2. Cells deleted for pom1 have a greater size distribution at mitosis compared with wild-type, which could suggest a role for Pom1 as a cell size sensor. PMID: 24047646
3. these data lead to a two-state model for gradient formation in which pom1p molecules associate with the plasma membrane at cell tips and then diffuse on the membrane while aggregating into and fragmenting from clusters, before disassociating from the membrane. PMID: 22342545
4. Study shows that Tea4, which is normally deposited at cell tips by microtubules, is both necessary and, upon ectopic cortical localization, sufficient to recruit Pom1 to the cell cortex. PMID: 21703453
5. Pom1 kinase acts as a negative regulator of Mid1p distribution, excluding Mid1p from non-growing ends, whereas a Pom1-independent mechanism prevents Mid1p association with growing ends. PMID: 17077120
6. Study provides evidence that pom1p, a DYRK-family protein kinase that forms a concentration gradient emanating from the nongrowing cell end, inhibits mid1p, in pom1 mutants, mid1p is distributed over half of the cell, covering the nongrowing cell end. PMID: 17140794
7. the cell polarity protein kinase Pom1, which localizes to cell ends, regulates a signalling network that contributes to the control of mitotic entry PMID: 19474789
8. an intracellular gradient of the dual-specificity tyrosine-phosphorylation regulated kinase (DYRK) Pom1, which emanates from the ends of rod-shaped Schizosaccharomyces pombe cells, serves to measure cell length and control mitotic entry PMID: 19474792

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KEGG: spo:SPAC2F7.03c

STRING: 4896.SPAC2F7.03c.1