tw Antibody

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Code	CSB-PA895241XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) tw Polyclonal antibody

Uniprot No.

Q9W5D4

Target Names

Alternative Names

tw antibody; Pomt2 antibody; CG12311 antibody; Protein O-mannosyl-transferase 2 antibody; EC 2.4.1.109 antibody; Dolichyl-phosphate-mannose--protein mannosyltransferase 2 antibody; DmPOMT2 antibody; dPOMT2 antibody; Protein twisted antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) tw protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

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Target Background

Function

Rt/POMT1 and tw/POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development.

Gene References into Functions

Study demonstrated that expression of RNA interference (RNAi) for the rt gene and the tw mutant was almost completely lethal and semi-lethal, respectively. PMID: 20644630
molecular cloning and characterization of POMT2 PMID: 12460945
Drosophila POMT1 and POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development. PMID: 15271988
establish a central role for Dystroglycan (Dg) in maintaining integrity in Drosophila larval muscles and demonstrate the importance of glycosylation to Dg function in Drosophila PMID: 17881734

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Protein Families

Glycosyltransferase 39 family

Tissue Specificity

At the cellular blastoderm stage, expression accumulates in the ventrally located mesoderm primordium. At germ band extension, mesoderm expression is seen as stripes of strong expression. A very strong signal is also detected in the invaginating gut. As t

Database Links

KEGG: dme:Dmel_CG12311

STRING: 7227.FBpp0070134

UniGene: Dm.12266

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tw Antibody

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