POT1A Antibody

Code CSB-PA704105XA01DOA
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Product Details

Full Product Name
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) POT1A Polyclonal antibody
Uniprot No.
Target Names
POT1A
Alternative Names
POT1A antibody; POT1 antibody; At2g05210 antibody; F5G3 antibody; Protection of telomeres protein 1a antibody; AtPOT1a antibody; AtPot1 antibody; Protection of telomeres protein 1 antibody
Raised in
Rabbit
Species Reactivity
Arabidopsis thaliana
Immunogen
Recombinant Arabidopsis thaliana POT1A protein
Immunogen Species
Arabidopsis thaliana (Mouse-ear cress)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the positive regulation of telomere length. Binds RNA non-specifically. Binds specifically single-stranded telomeric DNA. Not required to recruit telomerase to telomeres, but stimulates TER1 RNP repeat addition processivity.
Gene References into Functions
  1. POT1a promotes an extendable telomere state via contacts with the telomerase RNP as well as STN1 and CTC1, while TEN1 opposes these functions. PMID: 25329641
  2. Our results reveal a molecular mechanism for the role of these positively selected sites in AtPOT1a. PMID: 25697340
  3. AtPot1 (protection of telomeres 1) and AtPot2 are ubiquitously expressed at low levels in Arabidopsis. AtPot1 is essential for telomere length maintenance. [Atpot1] PMID: 16107718
  4. Single-strand telomeric DNA binding activity present in A. thaliana nuclear extracts is not dependent on POT1a or POT1b proteins. PMID: 19228335
Subcellular Location
Nucleus. Chromosome, telomere. Nucleus, nucleolus. Cytoplasm.
Protein Families
Telombin family
Tissue Specificity
Expressed in roots, rosette leaves, cauline leaves, stems and flowers.
Database Links

KEGG: ath:AT2G05210

STRING: 3702.AT2G05210.1

UniGene: At.48422

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