let-92 Antibody

Code CSB-PA109488XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans let-92 Polyclonal antibody
Uniprot No.
Target Names
let-92
Alternative Names
let-92 antibody; F38H4.9 antibody; Serine/threonine-protein phosphatase 2A catalytic subunit antibody; PP2A antibody; EC 3.1.3.16 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans let-92 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Protein phosphatase which plays an essential role in early embryonic cell division. Probably together with constant regulatory subunit paa-1 and regulatory subunit sur-6, positively regulates centriole duplication by preventing the degradation of sas-5 and kinase zyg-1. In addition, plays a role in the recruitment of sas-6 and maybe sas-5 to centrioles and may dephosphorylate sas-5 and zyg-1 negative regulator szy-20. During vulva development, may play a role with regulatory subunits paa-1 and sur-6 in the induction of vulva cell precursors by positively regulating let-60/Ras-MAP kinase signaling, probably by promoting lin-45 activation. In association with regulatory subunit rsa-1 and probably paa-1, regulates microtubule outgrowth from centrosomes and mitotic spindle assembly ensuring the stability of kinetochore microtubules. Plays a negative role in axon guidance probably by dephosphorylating unc-51, unc-14 and vab-8.
Gene References into Functions
  1. PP2A cooperates with UNC-51 to regulate axon guidance by regulating phosphorylation. PMID: 20392746
Subcellular Location
Perikaryon. Cell projection, axon. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm.
Protein Families
PPP phosphatase family, PP-1 subfamily
Tissue Specificity
Ubiquitously expressed.
Database Links

KEGG: cel:CELE_F38H4.9

STRING: 6239.F38H4.9.1

UniGene: Cel.17866

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