pph-6 Antibody

Code CSB-PA600632XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans pph-6 Polyclonal antibody
Uniprot No.
Target Names
pph-6
Alternative Names
pph-6 antibody; C34C12.3 antibody; Serine/threonine-protein phosphatase 6 catalytic subunit antibody; EC 3.1.3.16 antibody; Protein phosphatase pph-6 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans pph-6 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Catalytic subunit of protein phosphatase 6 (PP6). In complex with saps-1, promotes actomyosin contractility during cytokinesis by regulating the organization of cortical non-muscle myosin II nmy-2 and thus contributing to correct spindle positioning. Also required for the proper generation of pulling forces on spindle poles during anaphase by regulating the cortical localization of gpr-1, gpr-2 and lin-5.
Gene References into Functions
  1. the complex of PPH-6 and SAPS-1 (PPH-6/SAPS-1) is required for contractility of the actomyosin network and proper spindle positioning PMID: 20040490
Subcellular Location
Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole.
Protein Families
PPP phosphatase family, PP-X subfamily
Database Links

KEGG: cel:CELE_C34C12.3

STRING: 6239.C34C12.3

UniGene: Cel.19977

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