pros Antibody

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Code	CSB-PA326906XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) pros Polyclonal antibody

Uniprot No.

P29617

Target Names

pros

Alternative Names

CG17228 antibody; Homeobox protein prospero antibody; Pro antibody; PROS 1 antibody; PROS 2 antibody; proS antibody; PROS_DROME antibody; PROS1 antibody; PROS2 antibody; Prosp antibody; Voila antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) pros protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Homeodomain protein that controls neuronal identity. As a transcriptional factor, regulates the expression of ftz, eve and en in a subset of neuroblast progeny and modulates the transcriptional activity of other homeodomain proteins such as Dfd. Required for proper neuronal differentiation, axonal outgrowth and pathfinding of most or all neurons and their precursors in central and peripheral nervous systems. Regulates asymmetric stem cell self-renewal together with brat.

Gene References into Functions

Loss of Prospero hinders the suppression of SCA8 associated neurodegeneration by Spoonbill. Prospero and Spoon might genetically interact and function together. PMID: 28722203
Prospero is required for the differentiation of astrocytes, but not of ensheathing glia, despite their common lineage. PMID: 26893340
Bj1 RanGEF promotes Prospero nuclear export and neuroblast self-renewal PMID: 25312250
Transient nuclear Prospero induces neural progenitor quiescence. PMID: 25354199
The results of this study suggested that Prospero restricts CO(2) neuron formation indirectly via miR-279 and directly by repressing the shared target molecules, Nerfin-1 and Esg. PMID: 22049409
the homeo-prospero domain coordinately regulates Prospero nuclear localization and DNA binding specificity PMID: 12429095
Subcellular localization of the transcription factor Prospero is dynamic. The carboxy terminus, including the homeodomain and Prospero domain, plays a roles in regulating these changes. PMID: 12529405
The complete development of the nervous system requires a full complement of Pros, and that a gradual decrease in the levels of this protein can proportionally alter the development and the function of the nervous system. PMID: 12605454
expression in combination with seven-up and elav identifies progenitor cell types during sense-organ differentiation in the Drosophila antenna PMID: 12606283
Pros is a transcription factor which controls the distinction between color photoreceptor cell fates. PMID: 12791270
Results identify an intron region critical for prospero twintron splicing as a first step towards elucidating the molecular mechanism of splicing regulation involving competition between the two kinds of spliceosomes. PMID: 14966268
The neural precursor gene prospero is essential for nerfin-1 expression in the developing Drosophila central nervous system. PMID: 15617679
DTRAF1 binds to Baz and acts downstream of Egr in the Mira/Pros telophase rescue pathway. PMID: 17139248
Spatio-temporal expression of Prospero is finely tuned to allow the correct development and function of the nervous system in Drosophila melanogaster. PMID: 17223099
Altered prospero expression affects the age of onset of male mating behavior. PMID: 17436071
In the compound eye, prospero (pros) is transcribed specifically in R7 photoreceptors and cone cells. PMID: 18635611
transcription factor transported to the nucleus during Drosophila embryonic nervous system development PMID: 11262236

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Subcellular Location

Nucleus. Cytoplasm, cell cortex. Cytoplasm.

Protein Families

Prospero homeodomain family

Database Links

KEGG: dme:Dmel_CG17228

STRING: 7227.FBpp0293146

UniGene: Dm.7116

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pros Antibody

Product Details

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Customer Reviews and Q&A

Target Background