PRP19 Antibody

1. we provide the first piece of evidence that the linker sequences outside the RNA recognition motif (RRM) - those connecting the ZnF domain and the RRM of the Prp19-associated complex - directly interact with RNA PMID: 21957909
2. New low abundance splicing factors connected to NTC (Nineteen Complex) function, provides evidence for distinct Prp19 containing complexes, and underscores the role of the Prp19 WD40 domain as a splicing scaffold. PMID: 21386897
3. hPRP19 interacts with PHD3 to suppress the cell death under hypoxic conditions by limiting the function of PHD3 which leads to caspase activation PMID: 20599946
4. Prp19p forms a tetramer in vitro and in vivo; the domain required for its oligomerization maps to a central tetrameric coiled-coil PMID: 15601865
5. Data suggest that the Prp19-associated complex is required for defining the specificity of interaction of U5 and U6 with the 5' splice site to stabilize their association with the spliceosome after U4 is dissociated. PMID: 15994330
6. The Prp19-associated complex has an indirect role in spliceosome recycling through affecting the biogenesis of U4/U6 snRNP in the in vivo splicing reaction. PMID: 16540691
7. Yju2 acts in concert with an unidentified heat-resistant factor(s) in an ATP-independent manner to promote the first catalytic reaction of pre-mRNA splicing after Prp2-mediated structural rearrangement of the spliceosome. PMID: 17515604

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KEGG: sce:YLL036C

STRING: 4932.YLL036C