Psc Antibody

Code CSB-PA339593XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Psc Polyclonal antibody
Uniprot No.
Target Names
Psc
Alternative Names
Psc antibody; CG3886 antibody; Polycomb group protein Psc antibody; Protein posterior sex combs antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Psc protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (BX-C) complexes, and hence for the maintenance of segmental determination.
Gene References into Functions
  1. Psc and Su(z)2 maintain somatic stem cell identity and activity in Drosophila. PMID: 23285219
  2. The Psc-Su(z)2 locus is flanked by insulator elements that may protect neighboring genes from inappropriate silencing. PMID: 22289633
  3. study describes a transcription-independent function for PSC in regulating the destruction of cyclin B; PSC appears to mediate both developmental gene silencing and posttranslational control of mitosis PMID: 22491092
  4. Posterior sex combs (Psc), which encodes a core Polycomb-repressive complex 1 (PRC1) component, functions redundantly with a similar gene, Suppressor of zeste two [Su(z)2], to restrict follicle stem cell (FSC) self-renewal in the Drosophila ovary PMID: 20439432
  5. Psc encodes at least two functions, complex formation and the inhibition of remodeling and transcription, which require different regions of the protein. PMID: 16024794

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Subcellular Location
Nucleus.
Database Links

KEGG: dme:Dmel_CG3886

STRING: 7227.FBpp0086911

UniGene: Dm.2703

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