PSK1 Antibody

Code CSB-PA327041XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PSK1 Polyclonal antibody
Uniprot No.
Target Names
PSK1
Alternative Names
PSK1 antibody; YAL017W antibody; FUN31 antibody; YAL002 antibody; Serine/threonine-protein kinase PSK1 antibody; EC 2.7.11.1 antibody; PAS kinase 1 antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PSK1 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Serine/threonine-protein kinase involved in the control of sugar metabolism and translation. Phosphorylates UGP1, which is required for normal glycogen and beta-(1,6)-glucan synthesis. This phosphorylation shifts glucose partitioning toward cell wall glucan synthesis at the expense of glycogen synthesis.
Gene References into Functions
  1. Snf1 phosphorylates and activates Psk1. Once activated, Psk1 may phosphorylate Pbp1, which is known to stimulate stress granule formation and inhibit TORC1 through sequestration. Thus, Psk1 is a link between energy status and cell growth/proliferation. PMID: 25428989
  2. PSK1 mediated in vivo phosphorylation of Cbf1 at T211/T212 inhibits yeast cell respiration. PMID: 24850888
  3. Showed deletion of PSK1 increased sensitivity of yeast to ox. stress&partly inhibited cell growth; but the PSK2-deleted mutant was similar to that of the wild type. SOD1 mRNA and protein levels were lower in PSK1-deletion mutant than the wild type. PMID: 24236444
  4. Yeast PAS kinases phosphorylate UDP-glucose pyrophosphorylase, the primary producer of UDP-glucose and the glucose donor for glucan biosynthesis. PMID: 17531808
  5. PAS kinases PSK1 and PSK2 coordinate glucose partitioning in response to metabolic and cell integrity signaling PMID: 17989693

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Subcellular Location
Cytoplasm.
Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family
Database Links

KEGG: sce:YAL017W

STRING: 4932.YAL017W

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