rpn-10 Antibody

Code CSB-PA183605XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans rpn-10 Polyclonal antibody
Uniprot No.
Target Names
rpn-10
Alternative Names
rpn-10 antibody; B0205.3 antibody; 26S proteasome non-ATPase regulatory subunit 4 antibody; 26S proteasome regulatory subunit rpn-10 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans rpn-10 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Binds and presumably selects ubiquitin-conjugates for destruction. Required for protein degradation and ubiquitin-proteasome system (UBS) function and regulates proteasomal subunit expression. Involvement in UBS might be cell type specific. Regulator of the autophagy-lysosome pathway that may confer resistance to autophagy by regulating the expression of autophagy-related proteins such as lgg-1, and by regulating lysosome formation, possibly by modulating elt-2 activity. Required for fertility, sperm production, and sex determination through regulation of tra-2 protein. Plays a role in the elimination of paternal mitochondria in fertilized eggs.
Gene References into Functions
  1. These results show that the RPN-10-mediated ubiquitin pathway is indispensable for control of the TRA-2-mediated sex-determining pathway. PMID: 17050737
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Proteasome subunit S5A family
Tissue Specificity
Broadly expressed with high expression in the pharynx, intestine, hypodermis and spermatheca and weak expression in the excretory cell, body wall muscle, vulva and somatic gonad.
Database Links

KEGG: cel:CELE_B0205.3

STRING: 6239.B0205.3.2

UniGene: Cel.5538

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