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sel-12 Antibody

Datasheet
Code CSB-PA344766XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans sel-12 Polyclonal antibody
Uniprot No.
P52166
Target Names
sel-12
Alternative Names
sel-12 antibody; F35H12.3 antibody; Presenilin sel-12 antibody; Suppressor/enhancer of lin-12 protein 12 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans sel-12 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Related Products

sel-12 Proteins

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Target Background

Function
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling.
Gene References into Functions
  1. mutations in sel-12 result in defects in calcium homeostasis, leading to mitochondrial dysfunction PMID: 26500256
  2. A genetic null allele mutant, sel-12(ar171), showed resistance to oxidative stress and prevented mitochondrial dysfunction-induced apoptosis. PMID: 12556527
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein Families
Peptidase A22A family
Tissue Specificity
Expressed in most neurons.
Database Links

KEGG: cel:CELE_F35H12.3

STRING: 6239.F35H12.3

UniGene: Cel.19557

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