Psn Antibody

1. Psn is required for neuronal survival during aging and normal lifespan. PMID: 28495961
2. findings suggest that a normal function of presenilin (PS)is to repress kinesin-1 and dynein motor activity during axonal transport of amyloid precursor protein (APP) vesicles; perturbations of APP/PS transport could contribute to early neuropathology observed in Alzheimer's Diseaseprecursor protein (APP) vesicles PMID: 23710041
3. a conserved role for presenilin in mediating copper uptake PMID: 23667524
4. The interaction of Sanpodo with Presenilin, a component of the gamma-secretase complex, is required for Notch activation. PMID: 23609534
5. Consistent with its role in Psn processing, Hbs genetically interacts with the Drosophila beta-amyloid protein precursor-like (Appl) protein. PMID: 22814602
6. Loss of presenilin causes significantly decreased Notch signaling and neuron apoptosis and increased cytoplasm calcium. PMID: 22120070
7. presenilin plays a role in regulating intracellular calcium stores PMID: 19730737
8. Drosophila PS (Psn) protein undergoes endoproteolytic cleavage and forms a stable high molecular weight (HMW) complex PMID: 12388554
9. specific diaspartyl groups within the presenilin catalytic core of gamma-secretase mediate the cleavage of different substrates PMID: 15220354
10. presenilin, nicastrin, APH-1, and PEN-2, are present and enriched on phagosome membranes from both murine macrophages and Drosophila S2 phagocytes PMID: 16103123
11. Psn familial Alzheimer's disease mutant activities were tightly linked to their age-of-onset values, providing evidence that disease severity in humans primarily reflects differences in PS mutant lesions. PMID: 16713961
12. evidence of learning and synaptic defects in a Drosophila psn mutant and strongly suggest a presynaptic role for presenilin in normal neuronal function. PMID: 17562530

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KEGG: dme:Dmel_CG18803

STRING: 7227.FBpp0077850

UniGene: Dm.3254