ptc Antibody

1. a mutation of the PTC PY motif, which mediates binding of C2-WW-HECT family members, inhibits its internalization but not its autonomous and non-autonomous signalling activities. the two related UB-C2-WW-HECT ligases NEDD4 and SU(DX) regulate PTC trafficking and finely tune its accumulation through partially redundant but distinct functions PMID: 26446620
2. Kto-Skd affects the A/P-axial development of the whole wing disc. Kto can interact with Cubitus interruptus (Ci), bind to the Ci-binding region on ptc promoter, which are both regulated by Hh signals to down-regulate ptc expression. PMID: 24962581
3. in vivo study demonstrates that the PI3K-cIII complex is essential for downregulating Patched via the endosomal-lysosomal pathway to execute axon pruning PMID: 25458013
4. Self-induced patched receptor down-regulation modulates cell sensitivity to the hedgehog morphogen gradient. PMID: 20736483
5. hedgehog (Hh) promotes the entry of Sxl into the nucleus in the wing disc; in the anterior compartment, Patched (Ptc) is required for this effect, revealing Ptc as a positive effector of Hh PMID: 14597576
6. finding suggests that dominant-negative function can be conferred by interruption of different aspects of Patched protein behaviour PMID: 15042702
7. Patched (Ptc), the Hh receptor, restrains both Hedgehog spreading and Hedgehog signaling. PMID: 15102702
8. results support a model in which the ratio of bound to unbound Ptc molecules determines the cellular response to Hedgehog PMID: 15300262
9. the Hh/Ptc complex is internalized in the Rab7-enriched lysosomal compartment in a Ptc-dependent manner without the co-receptor Smoothened (Smo). PMID: 15572139
10. The role of Patched (Ptc) in regulating the guidance of medial tract, one of the longitudinal tracts in the nerve cord, is investigated. PMID: 15754211
11. Ptc, as well as truncated Ptc deleted of its C-terminal domain, forms a stable trimer. This observation is consistent with the proposal that Ptc is structurally similar to trimeric transporters. PMID: 16980583
12. lipophorins internalization does not play a major role in Hedgehog (Hh) signal transduction but does in Hh gradient formation PMID: 18198278

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KEGG: dme:Dmel_CG2411

STRING: 7227.FBpp0088443