otk Antibody

Code CSB-PA715250XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) otk Polyclonal antibody
Uniprot No.
Target Names
otk
Alternative Names
otk antibody; CG8967 antibody; Tyrosine-protein kinase-like otk antibody; Gp160-Dtrk antibody; Dtrk antibody; Off-track antibody; Tyrosine-protein kinase-like 7 homolog antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) otk protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons.
Gene References into Functions
  1. Overexpression of Otk causes female sterility due to malformation of the oviduct, indicating that Otk and Otk2 are specifically involved in the sexually dimorphic development of the genital tract. PMID: 25010066
  2. Otk is a receptor or a component of a receptor complex that recognizes a target-derived signal for R cell 1-R cell 6 axons to innervate the lamina layer PMID: 15456725
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
Tissue Specificity
Dynamically expressed during embryogenesis in several areas of the developing nervous system, including neurons and fasciculating axons. Expression in stage 7 embryos is seen in the anterior midgut primordia, cephalic furrow and along the germinal band. A
Database Links

KEGG: dme:Dmel_CG8967

STRING: 7227.FBpp0087135

UniGene: Dm.2582

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