Ptp10D Antibody

Code CSB-PA339619XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Ptp10D Polyclonal antibody
Uniprot No.
Target Names
Ptp10D
Alternative Names
Ptp10D antibody; CG1817 antibody; Tyrosine-protein phosphatase 10D antibody; EC 3.1.3.48 antibody; Receptor-linked protein-tyrosine phosphatase 10D antibody; DPTP10D antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Ptp10D protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
May have a role in axon outgrowth and guidance.
Gene References into Functions
  1. through a genetic screen in Drosophila, we identify the ligand Sas and the receptor-type tyrosine phosphatase PTP10D as the cell-surface ligand-receptor system that drives tumour-suppressive cell competition PMID: 28092921
  2. The study of this study showed that neuronal Ptp10D restrains signaling by overexpressed glial Sas, which would otherwise produce strong glial and axonal phenotypes. PMID: 23764287
  3. Described is the crystal structures of Drosophila melanogaster PTP10D in the apo form as well as in a complex with a substrate peptide and an inhibitor. PMID: 22007620
  4. Our data clearly demonstrate that signaling through PTP10D in mushroom bodies is critical for the formation of long-term memory. PMID: 17442824
  5. Ptp10D is expressed only on the innermost core fibers during development of the larval mushroom body. PMID: 18356078

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Protein-tyrosine phosphatase family, Receptor class subfamily
Tissue Specificity
In 9-12 hour embryos, expression is specifically seen in the anterior commissure and its junctions with the longitudinal tracts.
Database Links

KEGG: dme:Dmel_CG1817

STRING: 7227.FBpp0303419

UniGene: Dm.7386

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