Ptp61F Antibody

Code CSB-PA895685XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Ptp61F Polyclonal antibody
Uniprot No.
Target Names
Ptp61F
Alternative Names
Ptp61F antibody; CG9181 antibody; Tyrosine-protein phosphatase non-receptor type 61F antibody; EC 3.1.3.48 antibody; dPTP61F antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Ptp61F protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Non-receptor protein tyrosine phosphatase required for maintaining Dock in its non-phosphorylated state.
Gene References into Functions
  1. Examination of the epistatic relationship between candidate genes and Stat92E reveals that Ptp61F and brm interact with Stat92E during both border cell specification and migration. PMID: 27175018
  2. Modulation of hyperactive MAP kinase activity by Ptp61F alleles, the phosphatase intervenes to directly or indirectly to regulate MAP kinase. PMID: 24752400
  3. The PTP61F variants differ in their capacities to regulate growth. PMID: 23339871
  4. Data show that more than 10,000 phosphorylation sites in the phosphoproteome were detected in Drosophila cells phosphatase Ptp61F knocked down by RNAi. PMID: 19429919
  5. identification of DPTP61F as responsible for maintaining Dock in its non-phosphorylated state PMID: 12014990
  6. These findings suggest that the reciprocal regulation of Abi phosphorylation by Abl and PTP61F may regulate the localization and stability of Abi and may regulate the formation of lamella. PMID: 17804420
  7. Ptp61F is a novel modulator of TOR activity PMID: 18653470
  8. Results establish that PTP61F and dAbl ensure proper actin organization through the coordinated and reversible tyrosine phosphorylation of Kette. PMID: 19398577

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Subcellular Location
[Isoform A]: Cytoplasm. Endomembrane system. Note=Associates with the membranes of the reticular network and the mitochondria.; [Isoform B]: Nucleus.
Protein Families
Protein-tyrosine phosphatase family, Non-receptor class 1 subfamily
Tissue Specificity
Expressed during oogenesis and embryogenesis. Isoform A and isoform B are expressed in distinct patterns. Isoform B is expressed in the mesoderm and neuroblast layer during germband extension and later in the gut epithelia. Isoform A accumulates in 16 seg
Database Links

KEGG: dme:Dmel_CG9181

STRING: 7227.FBpp0072602

UniGene: Dm.1991

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