RRD1 Antibody

Code CSB-PA331172XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) RRD1 Polyclonal antibody
Uniprot No.
Target Names
RRD1
Alternative Names
RRD1 antibody; NCS1 antibody; YPA1 antibody; YIL153W antibody; Serine/threonine-protein phosphatase 2A activator 1 antibody; EC 5.2.1.8 antibody; Peptidyl-prolyl cis-trans isomerase PTPA-1 antibody; PPIase PTPA-1 antibody; Rotamase PTPA-1 antibody; Phosphotyrosyl phosphatase activator 1 antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) RRD1 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for TAP42-associated PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex. Involved in the regulation of cell cycle progression, mitotic spindle formation, bud morphogenesis and DNA repair.
Gene References into Functions
  1. overexpression of RRD1 confers resistance to isoflurane PMID: 19774547
  2. Rrd1 (Ptpa1) forms a complex with Sit4 that mediates repair of oxidative DNA damage caused by 4-nitroquinoline-1-oxide and Ultraviolet A. PMID: 15150670
  3. specific interaction of Rrd1 with the Tap42-Sit4 complex and that of Rrd2 with the Tap42-Phosphoprotein Phosphatase 2Ac complex PMID: 15689491
  4. The crystal structures of Ypa1 was determined, revealing an all alpha-helical protein fold that is radically different from other PPIases. PMID: 16885030
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
PTPA-type PPIase family
Database Links

KEGG: sce:YIL153W

STRING: 4932.YIL153W

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