clr-1 Antibody

Code CSB-PA957456XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans clr-1 Polyclonal antibody
Uniprot No.
Target Names
clr-1
Alternative Names
clr-1 antibody; F56D1.4 antibody; Receptor-type tyrosine-protein phosphatase antibody; EC 3.1.3.48 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans clr-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Possesses an intrinsic protein tyrosine phosphatase (PTPase) activity. Regulates egl-15 activity which is required for hypodermis-mediated fluid homeostasis and protein degradation in muscle. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine. Regulates synaptic levels of nAchR subunit lev-1 in the nerve cord. Promotes the outgrowth of the quaternary dendritic branches of the PVD sensory neurons. In parallel to the sax-7/mnr-1 pathway, also controls the extension of the PVD primary branches. Acts in the netrin/DCC pathway to mediate the formation of synapses between the AVA interneurons and the PHB sensory neurons. Also required for the formation of synapses between the AVA interneurons and the VA10 motor neurons.
Gene References into Functions
  1. Data show that the receptor protein tyrosine phosphatase (RPTP) clr-1 is necessary for synaptic partner recognition (SPR) between the PHB sensory neurons and the AVA interneurons. PMID: 29742100
  2. CLR-1 acts in C. elegans skin cells to promote sensory dendrite outgrowth PMID: 26968353
Subcellular Location
Cell membrane; Single-pass membrane protein. Cell junction, synapse.
Protein Families
Protein-tyrosine phosphatase family, Receptor class 2A subfamily
Tissue Specificity
Expressed in muscles, hypodermis and a subset of neurons. Expressed in the AVA neurons, with high expression in the anterior half of the preanal ganglion where AVA neurons contact the PHB neurons.
Database Links

KEGG: cel:CELE_F56D1.4

STRING: 6239.F56D1.4b

UniGene: Cel.14960

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