qkia Antibody

Code CSB-PA750779XA01DIL
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Product Details

Full Product Name
Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) qkia Polyclonal antibody
Uniprot No.
Target Names
qkia
Alternative Names
qkia antibody; qkProtein quaking-A antibody; zqk antibody
Raised in
Rabbit
Species Reactivity
Danio rerio (Zebrafish) (Brachydanio rerio)
Immunogen
Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) qkia protein
Immunogen Species
Danio rerio (Zebrafish) (Brachydanio rerio)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of some pre-mRNA. Acts as a translational repressor.
Gene References into Functions
  1. This work uncovers a Quaking/Tpm3 pathway controlling de novo myofibril assembly. PMID: 28867488
  2. qkia is an ancestral paralog of the single tetrapod Qk gene that was likely lost during the fin-to-limb transition. qkia is not expressed in the progenitor domains of the central nervous system. PMID: 26727370
  3. Fine-tuning of Hh signaling by the RNA-binding protein Quaking to control muscle development. PMID: 21447554
Subcellular Location
Nucleus. Cytoplasm.
Database Links

KEGG: dre:30471

UniGene: Dr.75774

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