rab-6.1 Antibody

Datasheet

Code	CSB-PA339426XA01CXY
Size	Enquire
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans rab-6.1 Polyclonal antibody

Uniprot No.

P34213

Target Names

rab-6.1

Alternative Names

rab-6.1 antibody; F59B2.7 antibody; Ras-related protein Rab-6.1 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans rab-6.1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

■ Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. In its active GTP-bound form, acts redundantly with rab-6.2 (in its active GTP-bound form) to positively regulate the retrograde trafficking of cargo molecules from endosomes to Golgi structures. Required for the retrograde trafficking of glr-1, a subunit of AMPA-type glutamate receptors (AMPRs), out of early endosomes and into the Golgi compartment in neurons. Together with rab-6.2, promotes the retrograde trafficking of mig-14 from endosomes to Golgi structures in the intestine. In oocytes, in its active GTP-bound form, involved in the membrane fusion and exocytosis of secretory vesicles (cortical granules) to play a role in the remodeling of the embryo surface following fertilization. Recruits sep-1 to cortical granules (derived from the Golgi complex) for exocytosis during the oocyte-to-embryo transition. Required for seam cell division and alae formation. Promotes spontaneous reversals in locomotion.

Gene References into Functions

RAB-6.1 is an important molecule for the timely exocytosis of the cortical granules during oocyte-to-embryo transition. PMID: 22992455

Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, dendrite. Perikaryon. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle.

Protein Families

Small GTPase superfamily, Rab family

Tissue Specificity

Highly expressed in body wall muscle, intestine, somatic gonad, distal tip cells, vulva, and neurons including AVB, AVD, RIG, and PVC (at protein level). Not expressed in AVA and RMDV neurons.

Database Links

KEGG: cel:CELE_F59B2.7

STRING: 6239.F59B2.7.1

UniGene: Cel.10374

Promotions

Transmembrane Protein Questionnaire with Gifts

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

Join us with

Subscribe newsletter

Leave a message

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

rab-6.1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background