Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans rab-6.2 Polyclonal antibody

Uniprot No.

Q22782

Target Names

rab-6.2

Alternative Names

rab-6.2 antibody; T25G12.4 antibody; Ras-related protein Rab-6.2 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans rab-6.2 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. In its active GTP-bound form, acts redundantly with rab-6.1 (in its active GTP-bound form) to positively regulate the retrograde trafficking of cargo molecules from endosomes to the Golgi compartment. Required for the retrograde trafficking of glr-1, a subunit of AMPA-type glutamate receptors (AMPRs), out of early endosomes and into the Golgi compartment in neurons. Its role in glr-1 trafficking may partly be mediated by its interaction with lin-10 and association with components of the retromer complex such as rme-8. Together with rab-6.2, promotes the retrograde trafficking of mig-14 from endosomes to Golgi structures in the intestine. Plays a role in the epidermis to promote cuticle integrity and impermeability of the cuticle barrier to exogenous molecules. May have a role in the glycosylation of the cuticular surface. Required for seam cell division and alae formation. Required for grinder formation, which is the feeding organ that breaks down food. In contrast to rab-6.1, may play a minor role in the exocytosis of secretory vesicles (cortical granules) during the oocyte-to-embryo transition.

Gene References into Functions

RAB-6.2 and LIN-10 recycle AMPARs along a retrograde transport pathway in neurons so as to maintain synaptic strength. PMID: 22213799

Subcellular Location

Perikaryon. Cell projection, dendrite. Golgi apparatus. Cytoplasmic vesicle.

Protein Families

Small GTPase superfamily, Rab family

Tissue Specificity

Highly expressed in body wall muscles, pharyngeal and vulval muscles, hypodermis, intestine, the gonad, coelomocytes, and neurons, including command interneuron (at protein level). Highly expressed in the terminal bulb muscles.

Database Links

KEGG: cel:CELE_T25G12.4

STRING: 6239.T25G12.4

UniGene: Cel.38941

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rab-6.2 Antibody

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