rad22 Antibody

Code CSB-PA330608XA01SXV
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Product Details

Full Product Name
Rabbit anti-Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) rad22 Polyclonal antibody
Uniprot No.
Target Names
rad22
Alternative Names
rad22 antibody; SPAC30D11.10 antibody; DNA repair and recombination protein rad22 antibody
Raised in
Rabbit
Species Reactivity
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Immunogen
Recombinant Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) rad22 protein
Immunogen Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Active in the repair of DNA damage and in mating-type switching. Probably involved in the repair of DNA double-strands breaks. Has a role in promoting S phase completion.
Gene References into Functions
  1. Rad52 protein function study by fluorescne tagging.Rad22 protein tagging,a S. pombe is a Rad52 homologue.Presence of tagged Rad22 protein was confirmed by Western-blot and fluorescence microscopy. PMID: 24340529
  2. Rad22 plays dual roles in regulating meiotic recombination: activating Rad51 and inhibiting Dmc1. PMID: 24186976
  3. Rad22 can promote strand invasion to form a D-loop that can be cleaved by Mus81 PMID: 15486206
  4. Gel-filtration experiments and electron microscopic analyses indicate self-association of Rad22A and Rad22B and the formation of multimeric structure. PMID: 17208257
  5. mediates the formation and branch migration of Holliday recombination intermediates. (review) PMID: 18788459

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Subcellular Location
Nucleus.
Protein Families
RAD52 family
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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