RAD26 Antibody

1. structure of the S. cerevisiae Pol II-Rad26 complex solved by cryo-electron microscopy; structure reveals that Rad26 binds to the DNA upstream of Pol II, where it markedly alters its path; structural and functional data suggest that the conserved Swi2/Snf2-family core ATPase domain promotes the forward movement of Pol II, and elucidate key roles for Rad26 in both TCR and transcription elongation PMID: 29168508
2. Rad26 may facilitate transcription coupled nucleotide excision repair (TC-NER) indirectly, by antagonizing the action of TC-NER repressors that normally promote transcription elongation. PMID: 26429063
3. Data indicate that RAD26 deletion does not reduce expression of nucleotide excision repair (NER) factors but affects RPB2 transcription during NER. PMID: 23991048
4. Rad26p promotes the eviction of histone H2A-H2B dimer and hence chromatin disassembly. PMID: 22794311
5. Rad26p does not recognize DNA lesions in the absence of active transcription. PMID: 20007604
6. Spt5 CTR suppresses Rad26-independent TCR by serving as a platform for assembly of a multiple protein suppressor complex that is associated with Pol II. PMID: 20042611
7. Rad26 plays a significant role in repairing certain regions of the repressed GAL1-10, PHO5 and ADH2 genes, especially in the core DNA of well-positioned nucleosomes PMID: 17611170

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KEGG: sce:YJR035W

STRING: 4932.YJR035W