Rad52 Antibody

Code CSB-PA019269XA01MO
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Rad52 Polyclonal antibody
Uniprot No.
Target Names
Rad52
Alternative Names
Rad52 antibody; DNA repair protein RAD52 homolog antibody
Raised in
Rabbit
Species Reactivity
Mus musculus (Mouse)
Immunogen
Recombinant Mus musculus (Mouse) Rad52 protein
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.
Gene References into Functions
  1. Suppression of Rad52 expression in combination with FANCM knockout drastically reduces cell and tumor growth, suggesting a synthetic lethality interaction between these two genes. PMID: 30022024
  2. Rad52 competes with Ku for binding to S-region double-strand DNA breaks (DSB) free ends, where it facilitates a DSB synaptic process, which favours intra-S region recombination. PMID: 28176781
  3. Results demonstrate that Rad52 depletion increased cell death, decreased myeloid cell frequency, and augmented the activity of CD8+ T cells and NK effectors that ultimately led to reduced tumor growth. These data provide support for the notion of RAD52 as a potential oncogene, implicating a major role for the combined processes of recombinational repair and host immunity in determining risk for Squamous Cell. PMID: 28415565
  4. In cancer-prone, heterozygous APC mutant mice, homozygous deletion of the Rad52 gene suppressed tumor growth and prolonged lifespan. PMID: 27984746
  5. Rad54 has a key function in maintaining genomic integrity of the developing germ cells. PMID: 23949223
  6. Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm-deficient mice. PMID: 15122331
  7. RAD52 modulates the outcome of recombinant HIV-l vector infection by markedly reducing the efficiency of productive integration events PMID: 15297876
  8. Inactivation of RAD52 aggravates X-ray and mitomycine C sensitivity in mice with RAD54 gene degect. PMID: 16009599
  9. Cells expressing Rad52 splice variants favor sister chromatid repair. PMID: 16648471
  10. Results indicate that RAD52 cooperates with OGG1 to repair oxidative DNA damage and enhances the cellular resistance to oxidative stress. PMID: 19506022

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Subcellular Location
Nucleus.
Protein Families
RAD52 family
Database Links

KEGG: mmu:19365

STRING: 10090.ENSMUSP00000125502

UniGene: Mm.149

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