Ran Antibody

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Code	CSB-PA894758XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Ran Polyclonal antibody

Uniprot No.

Q9VZ23

Target Names

Ran

Alternative Names

Ran antibody; Ran10A antibody; CG1404 antibody; GTP-binding nuclear protein Ran antibody; Ras-related nuclear protein antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Ran protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. GTP-bound Ran modulates both spindle and nuclear envelope assembly, supporting a role during mitosis. During oogenesis, modulates formation of Nup358-containing granules and biogenesis of the nuclear pore complex probably by mediating the transport of their components along microtubules.

Gene References into Functions

Results demonstrate that Ran is associated with the resistance to and tolerance of multiple pesticides. PMID: 29680247
RanGTP is required for meiotic spindle organization and the initiation of embryonic development. PMID: 22100918
the Canoe Ras-association (RA) domains directly bind RanGTP PMID: 22024168
Knockdown of the small G protein Ran, which is essential for nuclear transport, leads to an arrest of EcR in the cytoplasm, but does not prevent efficient nuclear import of the most important heterodimerization partner of EcR, ultraspiracle (Usp). PMID: 21125558
gtpase ran localizes around the microtubule spindle in vivo during mitosis in Drosophila embryos PMID: 12121620

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Subcellular Location

Nucleus. Nucleus envelope. Cytoplasm. Cytoplasm, cytoskeleton, spindle.

Protein Families

Small GTPase superfamily, Ran family

Database Links

KEGG: dme:Dmel_CG1404

STRING: 7227.FBpp0073328

UniGene: Dm.6755

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Ran Antibody

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