Rap1 Antibody

1. Rap1-interacting domains of Canoe mediate adherens junction and tricellular junction recruitment but are dispensable for membrane localization. Data also support a role for Canoe multimerization. These multifactorial inputs shape Canoe localization, correct Bazooka and adherens junction positioning, and thus apical-basal polarity. PMID: 29361565
2. Gain-of-function studies using dominant-negative and constitutively active forms of Rap1 indicate that Rap1 contributes to axonal growth and guidance. PMID: 27565025
3. Rap1 is activated to its GTP-bound form in response to Hh ligand, and that the GTPase exchange factor C3G likely contributes to this activation. PMID: 26481064
4. According to Bridges' map, all three bands (Dras1, Dras2, Dras3) were mapped to regions 85D, 64B, and 62B of chromosome 3. Among them, only Drasl has a common origin with ras genes of mammals. PMID: 25434202
5. Increased Rap1 activity restricts epithelial invagination in an alpha-catenin-dependent manner. PMID: 23623612
6. The Rap1 is slightly enriched at the apical pole of metaphase/anaphase NBs and was found in a complex with atypical protein kinase C and Par6 in vivo. PMID: 22084305
7. Rap1 has a role in determining cell-type-specific morphologies in the developing wing epithelium. Rap1, with its effector Canoe, promotes symmetric distribution of DE-cadherin about the apicolateral circumference of epithelial cells. PMID: 22776378
8. enriched at adherens junctions, particularly between newly divided sister cells where it may reseal the adherens junction ring PMID: 11847339
9. Rap1 mediates Ras-independent activation of ERK signaling via the torso receptor tyrosine kinase in Drosophila embryos. PMID: 15723799
10. Rap1 acts through the effector Canoe to regulate these developmental processes. PMID: 19576205

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KEGG: dme:Dmel_CG1956

STRING: 7227.FBpp0072746

UniGene: Dm.822