Rd3 Antibody

Datasheet

Code	CSB-PA805945XA01MO
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Product Details

Full Product Name

Rabbit anti-Mus musculus (Mouse) Rd3 Polyclonal antibody

Uniprot No.

Q8BRE0

Target Names

Rd3

Alternative Names

Rd3 antibody; Protein RD3 antibody; Retinal degeneration protein 3 antibody

Raised in

Rabbit

Species Reactivity

Mus musculus (Mouse)

Immunogen

Recombinant Mus musculus (Mouse) Rd3 protein

Immunogen Species

Mus musculus (Mouse)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors. Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2E and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors. Involved in the transport of GUCY2E and GUCY2F to their target sites in the photoreceptor outer segment. Up-regulates the activity of GUK1, a kinase that plays also an essential role for recycling GMP and indirectly, cGMP. Plays an important role for the survival of rods and cones in the retina.

Gene References into Functions

Study describes a mouse model of Leber's Congenital Amaurosis type 1 and 12 with autosomal recessive mutation in rd3 gene. The substitution mutation in the Rd3 gene is predicted to cause a stop codon after residue 106. PMID: 27150101
the main RetGC-binding interface on RD3 required for the negative regulation of the cyclase localizes to the Lys(87)-Leu(122) region. PMID: 27471269
Direct association between RD3 and GCAP1 is important for GC1 targeting. PMID: 25477517
Studies indicate that RD3 plays an essential role in the exit of guanylate cyclase from the endoplasmic reticulum and its trafficking to photoreceptor outer segments. PMID: 23740938
Changes in gene expression associated with photoreceptor degeneration in the rd3 mouse model of Leber congenital amaurosis (LCA) type 12, are characterized. PMID: 23687432
photoreceptor degeneration in the rd3 mouse, rcd2 dog, and LCA12 patients is caused by impaired RD3-mediated guanylate cyclase expression and trafficking PMID: 21078983
Rd3 is preferentially expressed in the retina and exhibits increasing expression through early postnatal development. PMID: 17186464

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Subcellular Location

Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Endosome. Nucleus. Cytoplasm. Cytoplasm, perinuclear region.

Tissue Specificity

Expressed in the retina and in particular in the inner nuclear layer, in rod and cone outer segments, in the outer nuclear layer, in the outer plexiform layer and in the ganglion cell layer.

Database Links

KEGG: mmu:74023

STRING: 10090.ENSMUSP00000050188

UniGene: Mm.274393

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Rd3 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background