UPF3A Antibody

Datasheet

Code	CSB-PA875647XA01HU
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) UPF3A Polyclonal antibody

Uniprot No.

Q9H1J1

Target Names

UPF3A

Alternative Names

2600001C03Rik antibody; 4930546M19Rik antibody; hUpf3 antibody; HUPF3A antibody; MGC151365 antibody; Nonsense mRNA reducing factor 3A antibody; OTTHUMP00000018789 antibody; Regulator of nonsense transcripts 3A antibody; REN3A_HUMAN antibody; RENT3A antibody; Up frameshift suppressor 3 homolog A antibody; Up-frameshift suppressor 3 homolog A antibody; UPF3 A antibody; UPF3 antibody; UPF3 regulator of nonsense transcripts homolog A antibody; upf3a antibody

Raised in

Rabbit

Species Reactivity

Homo sapiens (Human)

Immunogen

Recombinant Homo sapiens (Human) UPF3A protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation.

Gene References into Functions

The complex between the interacting domains of human UPF2 and UPF3b at a 1.95 A resolution. PMID: 15004547
hUpf3a is much less active than hUpf3b to induce NMD and to stimulate translation PMID: 16601204
The Upf complex communicates with the exon-junction complex and triggers nonsense-mediated decay in the cytoplasm. PMID: 17803942

Subcellular Location

Nucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm.

Protein Families

RENT3 family

Tissue Specificity

Isoform 1 is strongly expressed in testis, uterus, muscle, fetal brain and spinal cord. Isoform 2 is strongly expressed in fetal brain and spinal cord.

Database Links

HGNC: 20332

OMIM: 605530

KEGG: hsa:65110

STRING: 9606.ENSP00000364448

UniGene: Hs.533855

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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UPF3A Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background