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smg-2 Antibody

Datasheet
Code CSB-PA025650XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans smg-2 Polyclonal antibody
Uniprot No.
O76512
Target Names
smg-2
Alternative Names
smg-2 antibody; Y48G8AL.6 antibody; Regulator of nonsense transcripts 1 antibody; EC 3.6.4.- antibody; ATP-dependent helicase smg-2 antibody; Nonsense mRNA reducing factor 1 antibody; Up-frameshift suppressor 1 homolog antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans smg-2 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

Related Products

smg-2 Proteins

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Target Background

Function
RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an smg-2-3-4 surveillance complex is believed to activate NMD.
Gene References into Functions
  1. results suggest that the role of SMG-5 is to direct protein phosphatase 2A to its SMG-2 substrate PMID: 12554664
  2. SMG-2 interacts with SMG-3, SMG-3 interacts with SMG-4, and SMG-2 interacts indirectly with SMG-4 via shared interactions with SMG-3. SMG-2 preferentially associates with PTC-containing mRNAs. PMID: 17562857
Subcellular Location
Cytoplasm.
Protein Families
DNA2/NAM7 helicase family
Database Links
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