AC1 Antibody

Datasheet

Code	CSB-PA322055XA01AAE
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Target Background

Product Details

Full Product Name

Rabbit anti-Abutilon mosaic virus (isolate West India) (AbMV) AC1 Polyclonal antibody

Uniprot No.

P21947

Target Names

AC1

Alternative Names

AC1 antibody; AL1 antibody; Replication-associated protein antibody; Rep antibody; EC 2.7.7.- antibody; EC 3.1.21.- antibody; Protein AC1 antibody; Protein AL1 antibody

Raised in

Rabbit

Species Reactivity

Abutilon mosaic virus (isolate West India) (AbMV)

Immunogen

Recombinant Abutilon mosaic virus (isolate West India) (AbMV) AC1 protein

Immunogen Species

Abutilon mosaic virus (isolate West India) (AbMV)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Essential for the replication of viral ssDNA. The closed circular ssDNA genome is first converted to a superhelical dsDNA. Rep binds a specific region at the genome origin of replication. It introduces an endonucleolytic nick within the conserved sequence 5'-TAATATTAC-3' in the intergenic region of the genome present in all geminiviruses, thereby initiating the rolling circle replication (RCR). Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester. The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase. The polymerase synthesizes the (+) strand DNA by rolling circle mechanism. After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication. Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities.

Gene References into Functions

Rep (AC1) oligomers accumulated within the nucleoplasm and was able to transreplicate DNA B. PMID: 21840354

Subcellular Location

Host nucleus.

Protein Families

Geminiviridae Rep protein family

Database Links

KEGG: vg:956371

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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AC1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background