Product Details

Full Product Name

Rabbit anti-Mus musculus (Mouse) Rbfox1 Polyclonal antibody

Uniprot No.

Q9JJ43

Target Names

Rbfox1

Alternative Names

Rbfox1 antibody; A2bp antibody; A2bp1 antibody; Fox1 antibody; MNCb-3035 antibody; RNA binding protein fox-1 homolog 1 antibody; Ataxin-2-binding protein 1 antibody; Fox-1 homolog A antibody

Raised in

Rabbit

Species Reactivity

Mus musculus (Mouse)

Immunogen

Recombinant Mus musculus (Mouse) Rbfox1 protein

Immunogen Species

Mus musculus (Mouse)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.

Gene References into Functions

Study shows that Rbfox1-isoform1 plays an important role in neuronal migration and synapse network formation during corticogenesis. Defects in these critical processes may induce structural and functional defects in cortical neurons, and consequently contribute to the pathophysiology of neurodevelopmental disorders with RBFOX1 abnormalities. PMID: 27481563
Upon picrotoxin treatment, Rbfox1 expression was downregulated by miR-129-5p, thereby allowing the repression of Atp2b4 and Dcx. PMID: 28487411
Cytoplasmic Rbfox1 target mRNAs were enriched in genes involved in cortical development and autism PMID: 26687839
Rbfox1 regulates RNA splicing required for skeletal muscle structure and function. PMID: 25575511
Fox-1, expressed specifically in the neural cell stage, promoted Mef2c exon beta inclusion via the GCAUG. PMID: 20141540
The results suggest that in neuronal tissues A2BP1 plays important roles, which are regulated in a spatiotemporal manner. PMID: 23918472
our results suggest that a component of FSHD pathogenesis may arise by over-expression of FRG1, reducing Rbfox1 levels and leading to aberrant expression of an altered Calpain 3 protein through dysregulated splicing PMID: 23300487
Fox-1 splices mRNAs encoding proteins important in synaptic transmission and membrane excitation. PMID: 23027929
The splicing regulator Rbfox1 controls neuronal excitation in the mammalian brain. PMID: 21623373
These data indicate that A2BP1 mutations may clinically affect very selective forebrain neuron types from early periods of development. PMID: 21346316
These results demonstrate that the Fox protein family is playing a key role in tuning the properties of CaV1.2 calcium channels during neuronal development. PMID: 19564422
Fox-1/Ataxin 2-Binding Protein 1 (A2BP1), a protein implicated in a variety of neurological diseases, can counteract the effects of chronic depolarization on splicing PMID: 19762510

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Subcellular Location

Nucleus. Cytoplasm. Note=Predominantly nuclear.

Tissue Specificity

Detected in brain (at protein level). Detected in heart, brain, neurons, skeletal muscle and embryo.

Database Links

KEGG: mmu:268859

STRING: 10090.ENSMUSP00000049970

UniGene: Mm.370334

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Rbfox1 Antibody

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