Rbfox2 Antibody

1. These data reveal an alternative splicing program activated by Rbfox2 in the endothelium on recruitment of platelets and macrophages and demonstrate its relevance in transcriptional responses during flow-driven vascular inflammation. PMID: 29293084
2. This study demonstrated that the Rbfox2 represses e18a inclusion during pre-mRNA splicing of CaV2.2, limiting the size of CaV2.2 currents early in development in certain neuronal populations. PMID: 29067356
3. RBFOX2 dysregulation by dominant-negative RBFOX2 is an early pathogenic event in diabetic hearts. PMID: 27239029
4. RBFox2 interactis with chromatin in a nascent RNA-dependent manner. RBFox2 inactivation eradicates PRC2 targeting on the majority of bivalent gene promoters and leads to transcriptional de-repression. PMID: 27211866
5. A classic nuclear localization signal at the N terminus that regulates the subcellular localization of Rbfox2 isoforms during differentiation of the mouse epithelial and embryonic stem cells lines has been identified. PMID: 27859055
6. Gain- and loss-of-function experiments demonstrated that Rbfox1 and Rbfox2 cooperate in promoting Mef2D splicing and subsequent myogenesis. PMID: 25609712
7. Results show that the conserved Rbfox2 RNA binding protein regulates 30% of the splicing transitions observed during myogenesis and is required for the specific step of myoblast fusion. PMID: 25087874
8. an unexpectedly broad and multilayer regulatory network controlled by Rbfox2 and offer an explanation for how autoregulatory splicing networks are tuned PMID: 24637117
9. During an EMT, Rbfox2-regulated splicing shifts from epithelial-to mesenchymal-specific events. PMID: 23435423
10. Rbfox2 protein controls a post-transcriptional program required for proper brain development. PMID: 22357600
11. the negative regulation of Rbfox2 by Rbfox3 through a novel mechanism PMID: 21747913
12. The present study provides evidence that alternative neuronal nPTB and Fox-1/Fox-2 isoforms are also produced in lenses PMID: 21714144
13. Fox-1 and Fox-2 isoforms specifically activate splicing of neuronally regulated exons, which requires UGCAUG enhancer elements PMID: 16260614

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KEGG: mmu:93686

STRING: 10090.ENSMUSP00000130739

UniGene: Mm.202774