RGD1 Antibody

Code CSB-PA336439XA01SVG
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Product Details

Full Product Name Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) RGD1 Polyclonal antibody
Uniprot No. P38339
Target Names RGD1
Alternative Names RGD1 antibody; YBR260C antibody; YBR1728 antibody; RHO GTPase-activating protein RGD1 antibody; RhoGAP antibody; Related GAP domain protein 1 antibody
Raised in Rabbit
Species Reactivity Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) RGD1 protein
Immunogen Species Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

(From Uniprot)
GTPase activating protein of RHO3 and RHO4. Acts in concert with MID2 in cell integrity, which is functionally linked to the PKC pathway. Involved in various stress responses. Required at low pH for activation of the PKC pathway. Important during mating response.
Gene References into Functions
  1. demonstrate that Rgd1p is phosphorylated by the Aurora B like kinase Ipl1 and observe that loss of Ipl1 function leads to a new Rgd1p distribution in a small part of the cell population PMID: 23454383
  2. Rgd1p colocalizes with a subset of the post-golgi marker Sec2p and is transported to the bud tip. PMID: 22447923
  3. The authors propose that Tos2p, a protein involved in polarized growth and most probably associated with the plasma membrane, modulates the action of Rgd1p and Rho3p in Saccharomyces cerevisiae. PMID: 21143383
  4. the first evidences for a specific interaction between a RhoGAP domain (the RhoGAP domain of Rgd1p) and phosphoinositides were provided. PMID: 21215255
  5. The rgd1Delta strain is sensitive to low pH, and Rgd1p activates the PKC pathway in an acidic environment PMID: 16087742
  6. Phosphoinositides both regulate the recruitment and trafficking of Rgd1p to membranes via the F-BAR domain and specifically stimulate GTPase-activating protein activity PMID: 18845541

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Subcellular Location Cytoplasm. Note=Bud and bud neck. During isotropic bud growth in the G1 and S phases, detected at the bud tip. During cytokinesis, undetectable at the bud tip and localized at the bud neck only.
Database Links

KEGG: sce:YBR260C

STRING: 4932.YBR260C

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